Bio-Organic Chemistry: Enzyme Analysis
Topic: Fischer’s Lock & Key vs. Koshland’s Induced Fit
Figure 1: Geometric Simulation (2D Canvas)
Left: Lock & Key (Rigid entry). Right: Induced Fit (Enzyme morphs to fit substrate).
Figure 2: Mechanism Logic Flow
graph TD
subgraph Fischer[Lock and Key Model]
A[Substrate] -->|Fits Perfectly| B(Rigid Enzyme)
B --> C{No Change}
C --> D[Complex Formed]
end
subgraph Koshland[Induced Fit Model]
X[Substrate] -->|Approaches| Y(Flexible Enzyme)
Y -->|Binding Induces Change| Z{Active Site Morphs}
Z --> W[Transition State Stabilized]
end
style B fill:#222,stroke:#00e5ff,stroke-width:2px
style Y fill:#222,stroke:#ff4081,stroke-width:2px
Figure 3: 3D Structural Model (Interactive)
Interact: Click & Drag to rotate. Scroll to zoom.
Figure 4: Thermodynamic Profile
Key Differences
| Feature | Lock & Key | Induced Fit |
|---|---|---|
| Active Site | Rigid, Pre-formed | Flexible, Dynamic |
| Stabilization | Ground State (Trap) | Transition State (Catalysis) |
